Aim:
Epigenetics describes the heritable regulation of gene expression that is not directly encoded in the DNA sequence which is mediated by mechanisms such as covalent modification of DNA/histones and non-coding RNA. Stochastic and environment-induced deregulation of the epigenome contributes to diseases such as cancer and complex non-Mendelian disorders. Recent technological advancements such as DNA microarrays and high-throughput sequencing have provided biologists to understand the epigenetic processes at whole genome levels. These technologies generate large amounts of data which inevitably rely on systematic computational, bioinformatic tools in order to draw a definitive conclusion. The programme consists of a one-day symposium followed by a two-day workshop.
Symposium (January 10, 2013)
The symposium comprises of informative lectures by eminent experts in the field of epigenomics and cancer research. This will cover current perspectives in cancer epigenomics, experimental designs, high-throughput techniques for epigenomic analysis such as microarrays.
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Workshop (January 11-12, 2013)
The workshop will provide hands-on training on DNA microarray technologies for epigenetic analysis, data pre-processing, quality assessment and normalization, statistical analysis of data, functional analysis, interpretation and validation techniques.
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